13270-56-9
Chemical Structure
(S)-6-Methylnicotine
- CAS No.: 13270-56-9
- Formula:C11H16N2
- Molecular Weight:176.26
InChIKey: SWNIAVIKMKSDBJ-NSHDSACASA-N
SMILES: CN1[C@H](C2=CN=C(C)C=C2)CCC1
Biological Activity: (S)-6-Methylnicotine is a nicotinic acetylcholine receptor (nAChR) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine produces sensations identical to those of nicotine and has addictive potential. (S)-6-Methylnicotine shows high cytotoxicity against human bronchial epithelial cells and exerts a weak effect on the upregulation of lung cancer-related proteins. (S)-6-Methylnicotine can be used in the research of respiratory system diseases[1][2].
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(S)-6-Methylnicotine | (S)-6-Methylnicotine is a nicotinic acetylcholine receptor (nAChR) agonist that exhibits agonistic activity on isolated guinea pig ileum. (S)-6-Methylnicotine produces sensations identical to those of nicotine and has addictive potential. (S)-6-Methylnicotine shows high cytotoxicity against human bronchial epithelial cells and exerts a weak effect on the upregulation of lung cancer-related proteins. (S)-6-Methylnicotine can be used in the research of respiratory system diseases. | |||||||||||||||||||||
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- [1]. Pankow JF, et al. Levels of the nicotine analog 6-methyl nicotine as a naturally formed tobacco alkaloid in tobacco and tobacco products. Scientific reports. 2025 May 23;15(1):17945. [Content Brief]
- [2]. Jordt SE, et al. An electronic cigarette pod system delivering 6-methyl nicotine, a synthetic nicotine analog, marketed in the United States as "PMTA exempt". medRxiv [Preprint]. 2023 Nov 22:2023.11.21.23298778. [Content Brief]
Keywords
