133429-58-0
133429-58-0
Chemical Structure
Z-LLF-CHO
Synonym(s): Z-Leu-Leu-Phe-CHO
- CAS No.: 133429-58-0
- Formula:C29H39N3O5
- Molecular Weight:509.64
IUPAC Name: benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-phenylpropan-2-yl)amino)pentan-2-yl)amino)-1-oxopentan-2-yl)carbamate
InChIKey: LIOIGKLWXFXXEG-GSDHBNRESA-N
SMILES: O=C(N[C@H](C=O)CC1=CC=CC=C1)[C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O
Biological Activity: Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].
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Z-LLF-CHO | Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor. | |||||||||||||||||||||
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References
- [1]. Orlowski M, et al. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16;32(6):1563-72. [Content Brief]
- [2]. Ding L, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005 Sep;37(9):1881-9. [Content Brief]
