1335138-62-9
1335138-62-9
Chemical Structure
DS-1040
- CAS No.: 1335138-62-9
- Formula:C16H27N3O2
- Molecular Weight:293.40
IUPAC Name: (S)-5-amino-2-((1-((1r,4S)-4-methylcyclohexyl)-1H-imidazol-4-yl)methyl)pentanoic acid
InChIKey: AEHFUSPLVGWEEP-YDHLFZDLSA-N
SMILES: C[C@H]1CC[C@H](N2C=NC(C[C@@H](C(O)=O)CCCN)=C2)CC1
Biological Activity: DS-1040 is a low-molecular-weight imidazole derivative. DS-1040 is an inhibitor of the activated thrombin-activatable fibrinolysis (TAFIa). DS-1040 can promote fibrinolysis through suppressing TAFIa activity. DS-1040 can be studied in thrombolytic disease research[1][2].
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DS-1040 | DS-1040 is a low-molecular-weight imidazole derivative. DS-1040 is an inhibitor of the activated thrombin-activatable fibrinolysis (TAFIa). DS-1040 can promote fibrinolysis through suppressing TAFIa activity. DS-1040 can be studied in thrombolytic disease research. | |||||||||||||||||||||
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References
- [1]. Zhou, J., et al., (2017). A first-in-human study of DS-1040, an inhibitor of the activated form of thrombin-activatable fibrinolysis inhibitor, in healthy subjects. Journal of thrombosis and haemostasis : JTH, 15(5), 961-971. [Content Brief]
- [2]. Zhou, J., et al., (2019). First-in-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of an Oral Formulation of DS-1040, an Inhibitor of the Activated Form of Thrombin-Activatable Fibrinolysis Inhibitor, in Healthy Subjects. Journal of clinical pharmacology, 59(12), 1669-1677. [Content Brief]
