133575-27-6
Chemical Structure
Ara-F-NAD+
- CAS No.: 133575-27-6
- Formula:C21H26FN7O13P2
- Molecular Weight:665.42
IUPAC Name: 1-((2R,3S,4R,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-3-carbamoylpyridin-1-ium
InChIKey: JSGNSBZQCQQLEF-IVHCLJLKSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OC[C@@H]4[C@@H](O)[C@H](F)[C@H]([N+]5=CC=CC(C(N)=O)=C5)O4)([O-])=O)(O)=O)O3
Biological Activity: Ara-F-NAD+ is an arabino analogue of NAD+. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor[1][2].
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Ara-F-NAD+ | Ara-F-NAD+ is an arabino analogue of NAD+. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor. | |||||||||||||||||||||
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- [1]. Berthelier V, et al. Human CD38 is an authentic NAD(P)+ glycohydrolase. Biochem J. 1998;330 ( Pt 3)(Pt 3):1383-1390. doi:10.1042/bj3301383 [Content Brief]
- [2]. Wang S, et al. Design, synthesis and SAR studies of NAD analogues as potent inhibitors towards CD38 NADase. Molecules. 2014;19(10):15754-15767. Published 2014 Sep 29. [Content Brief]
Keywords
