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Ara-F-NAD+ 

Cat. No.: HY-134358
Handling Instructions

Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM.

For research use only. We do not sell to patients.

Ara-F-NAD+ Chemical Structure

Ara-F-NAD+ Chemical Structure

CAS No. : 133575-27-6

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Description

Ara-F-NAD+, an arabino analogue of NAD+, is a potent, slow-binding CD38 NADase inhibitor, with a Ki of 169 nM[1][2].

In Vitro

The leucoyte surface antigen CD38 has been shown to be an ecto-enzyme with multiple catalytic activities. It is principally a NAD+ glycohydrolase that transforms NAD+ into ADP-ribose and nicotinamide. CD38 is also able to produce small amounts of cyclic ADP-ribose (ADP-ribosyl cyclase activity) and to hydrolyse this cyclic metabolite into ADP-ribose (cyclic ADP-ribose hydrolase activity)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

665.42

Formula

C₂₁H₂₆FN₇O₁₃P₂

CAS No.
SMILES

O[[email protected]]1[[email protected]](O[[email protected]@H]([[email protected]]1O)COP(OP(OC[[email protected]]2O[C@]([N+]3=CC=CC(C(N)=O)=C3)([H])[[email protected]@H]([[email protected]@H]2O)F)([O-])=O)(O)=O)([H])N4C5=NC=NC(N)=C5N=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ara-F-NAD+OthersNADanaloguesauthenticcoenzymesslow-bindingInhibitorinhibitorinhibit

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