1338320-95-8
Chemical Structure
Antitumor agent-225
- CAS No.: 1338320-95-8
- Formula:C18H18N2O5S
- Molecular Weight:374.41
IUPAC Name: (E)-N-hydroxy-3-(1-((4-methoxyphenyl)sulfonyl)indolin-5-yl)acrylamide
InChIKey: LMFNVOGHSBJWLX-YCRREMRBSA-N
SMILES: O=C(C=CC1=CC=C2C(=C1)CCN2S(=O)(=O)C3=CC=C(OC)C=C3)NO
Biological Activity: Antitumor agent-225 is an orally effective and potent HDAC inhibitor with an IC50 value of 4.17 nM. Antitumor agent-225 inhibits HDAC activity by chelating zinc ions through its hydroxamic acid group, downregulates iNOS and COX-2 proteins, and suppresses the production of multiple inflammatory factors induced by LPS (HY-D1056). Antitumor agent-225 can be used for research on cancer and inflammation-related diseases[1].
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Antitumor agent-225 | Antitumor agent-225 is an orally effective and potent HDAC inhibitor with an IC50 value of 4.17 nM. Antitumor agent-225 inhibits HDAC activity by chelating zinc ions through its hydroxamic acid group, downregulates iNOS and COX-2 proteins, and suppresses the production of multiple inflammatory factors induced by LPS (HY-D1056). Antitumor agent-225 can be used for research on cancer and inflammation-related diseases. | |||||||||||||||||||||
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