13422-16-7
Chemical Structure
Triflocin
- CAS No.: 13422-16-7
- Formula:C13H9F3N2O2
- Molecular Weight:282.22
InChIKey: NLBIKXOJCISNQP-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CN=C1)O
Biological Activity: Triflocin is an orally active diuretic and Na+-K+-2Cl− cotransporter inhibitor with an IC50 of 3×10-5 M. Triflocin inhibits the outward basolateral electrogenic Na-(HCO3) n>1 cotransport in the proximal tubule. Triflocin has no tendency to induce hyperglycemia, and its blood glucose-elevating effect is extremely weak, such that an increase in blood glucose levels can only be detected under special conditions such as glucose loading. Triflocin is more prone to induce hypoglycemia[1][2].
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Triflocin | Triflocin is an orally active diuretic and Na+-K+-2Cl− cotransporter inhibitor with an IC50 of 3×10-5 M. Triflocin inhibits the outward basolateral electrogenic Na-(HCO3) n>1 cotransport in the proximal tubule. Triflocin has no tendency to induce hyperglycemia, and its blood glucose-elevating effect is extremely weak, such that an increase in blood glucose levels can only be detected under special conditions such as glucose loading. Triflocin is more prone to induce hypoglycemia. | |||||||||||||||||||||
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- [1]. Belachgar F, et al. Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule. Br J Pharmacol. 1994 Jun;112(2):465-70. [Content Brief]
- [2]. Gussin RZ, et al. The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog. Proc Soc Exp Biol Med. 1969 Sep;131(4):1258-62. [Content Brief]
Keywords
