134235-78-2
134235-78-2
Chemical Structure
CGS-22652
- CAS No.: 134235-78-2
- Formula:C22H29ClN2O4S
- Molecular Weight:452.99
IUPAC Name: 8-((4-chlorophenyl)sulfonamido)-4-(3-(pyridin-3-yl)propyl)octanoic acid
InChIKey: ISMHAZMNDUAHLK-UHFFFAOYSA-N
SMILES: ClC1=CC=C(S(=O)(NCCCCC(CCCC2=CN=CC=C2)CCC(O)=O)=O)C=C1
Biological Activity: CGS 22652 is a potent thromboxane A2 receptor antagonist. CGS 22652 has selective thromboxane A2 synthase inhibitory properties. CGS 22652 can be used in the research of coronary artery thrombosis[1][2].
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CGS-22652 | CGS 22652 is a potent thromboxane A2 receptor antagonist. CGS 22652 has selective thromboxane A2 synthase inhibitory properties. CGS 22652 can be used in the research of coronary artery thrombosis. | |||||||||||||||||||||
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References
- [1]. Cohen D S, et al. CGS 22652: A new potent thromboxane A2 receptor antagonist with selective thromboxane A2 synthase inhibitory properties. Cardiovascular drug reviews, 1992, 10(4): 379-391.
- [2]. Olson RW, et al. Beneficial effects of combined thromboxane synthase inhibition/receptor blockade with CGS 22652 in a canine model of coronary thrombosis. Eur J Pharmacol. 1993 May 12;236(1):75-87. [Content Brief]
Keywords
