135-09-1
135-09-1
Chemical Structure
Hydroflumethiazide
Synonym(s): Methforylthiazidine; Rontyl
- CAS No.: 135-09-1
- Formula:C8H8F3N3O4S2
- Molecular Weight:331.30
IUPAC Name: 6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
InChIKey: DMDGGSIALPNSEE-UHFFFAOYSA-N
SMILES: O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O
Biological Activity: Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].
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Hydroflumethiazide | 99.4% | Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas. | ||||||||||||||||||||
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Hydroflumethiazide (Standard) | ≥98% | Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas. | ||||||||||||||||||||
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Hydroflumethiazide-15N2,13C,d2 | Hydroflumethiazide-15N2,13C,d2 is the 13C- and 15N-labeled Hydroflumethiazide. | |||||||||||||||||||||
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Hydroflumethiazide-13C,d2 | Hydroflumethiazide-13C,d2 is the deuterium and 13C labeled Hydroflumethiazide. | |||||||||||||||||||||
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References
- [1]. Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11(1):103-7. [Content Brief]
- [2]. Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14(1):29-37. [Content Brief]
- [3]. Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34(8):784-9. [Content Brief]
