1353644-70-8
Chemical Structure
Theliatinib
Synonym(s): Xiliertinib; HMPL-309
- CAS No.: 1353644-70-8
- Formula:C25H26N6O2
- Molecular Weight:442.51
IUPAC Name: (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
InChIKey: FSXCKIBROURMFT-VGSWGCGISA-N
SMILES: O=C(N1C[C@]2([H])N(C)CC[C@]2([H])C1)NC3=CC4=C(NC5=CC=CC(C#C)=C5)N=CN=C4C=C3OC
Biological Activity: Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases[1]. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Theliatinib | 99.72% | Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Theliatinib (Standard) | ≥98% | Theliatinib (Standard) is the analytical standard of Theliatinib (HY-104066). This product is intended for research and analytical applications. Theliatinib (Xiliertinib) is a potent, ATP-competitive, orally active and highly selective EGFR inhibitor with a Ki of 0.05 nM and an IC50 of 3 nM. Theliatinib has an IC50 of 22 nM for EGFR T790M/L858R mutant. Theliatinib shows >50-fold selectivity for EGFR than other kinases. Theliatinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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Similarity Score 0.85
HY-104066ATheliatinib tartrate -
Similarity Score 0.78
HY-139300Epitinib -
Similarity Score 0.70
HY-139300AEpitinib succinate -
Similarity Score 0.59
HY-169948BML-265 -
Similarity Score 0.59
HY-19909ANRC-2694-A -
Similarity Score 0.58
HY-19909NRC-2694 -
Similarity Score 0.57
HY-13272RDacomitinib (Standard) -
Similarity Score 0.57
HY-Z4786Dacomitinib impurity 1 -
Similarity Score 0.57
HY-118263Dacomitinib hydrate -
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