1355994-75-0
1355994-75-0
Chemical Structure
ICT12035
Synonym(s): AZ2158
- CAS No.: 1355994-75-0
- Formula:C25H38N4O4S
- Molecular Weight:490.66
InChIKey: NDFKHRWYNVKHBS-SLFFLAALSA-N
SMILES: O=S(NC1=C(C(N[C@@H](C)C(C)(C)C)=O)C(C)=NN1[C@@H]2CC[C@@H](CC2)OC)(C3=CC=C(C=C3)C)=O
Biological Activity: ICT12035 (AZ2158) is a selective small-molecule FPR1 antagonist with an IC50 of 30 nM. ICT12035 reduces fMLF-induced proliferation and invasion and modulates xenograft tumor growth. ICT12035 is used in research on glioblastoma, bladder cancer, and glioma[1][2].
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ICT12035 | ICT12035 (AZ2158) is a selective small-molecule FPR1 antagonist with an IC50 of 30 nM. ICT12035 reduces fMLF-induced proliferation and invasion and modulates xenograft tumor growth. ICT12035 is used in research on glioblastoma, bladder cancer, and glioma. | |||||||||||||||||||||
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References
- [1]. Ahmet DS, et al. Application of small molecule FPR1 antagonists in the treatment of cancers. Scientific reports. 2020 Oct 14;10(1):17249.
- [2]. Li X, et al. (2021) An Exploration of the Tumor Microenvironment Identified a Novel Five-Gene Model for Predicting Outcomes in Bladder Cancer. Front. Oncol. 11:642527.
