135928-30-2
135928-30-2
Chemical Structure
Beloxepin
Synonym(s): Org 4428; ADL 6906
- CAS No.: 135928-30-2
- Formula:C19H21NO2
- Molecular Weight:295.38
IUPAC Name: (4aS,13bS)-2,10-dimethyl-1,3,4,13b-tetrahydrodibenzo[2,3:6,7]oxepino[4,5-c]pyridin-4a(2H)-ol
InChIKey: RPMDQAYGQBREBS-VQIMIIECSA-N
SMILES: O[C@@]12[C@@](CN(CC2)C)([H])C3=CC=CC(C)=C3OC4=CC=CC=C41
Biological Activity: Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects[1][2].
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Beloxepin | 98.04% | Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects. | ||||||||||||||||||||
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References
- [1]. Lorenzo Di Cesare Mannelli, et al. α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. Mini Rev Med Chem. 2017;17(2):95-107. [Content Brief]
- [2]. Craig T Hartrick. Noradrenergic reuptake inhibition in the treatment of pain. Expert Opin Investig Drugs. 2012 Dec;21(12):1827-34. [Content Brief]
Keywords
