1362243-70-6
1362243-70-6
Chemical Structure
Fluorizoline
- CAS No.: 1362243-70-6
- Formula:C15H8Cl2F3NS
- Molecular Weight:362.20
IUPAC Name: 2,5-bis(4-chlorophenyl)-4,4,5-trifluoro-4,5-dihydrothiazole
InChIKey: JGDLZQYCDVDWNE-UHFFFAOYSA-N
SMILES: FC1(C(F)(N=C(S1)C2=CC=C(C=C2)Cl)F)C3=CC=C(C=C3)Cl
Biological Activity: Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Fluorizoline | 99.77% | Fluorizoline selectively and directly binds to prohibitin 1 (PHB1) and 2 (PHB2), and induces apoptosis. Fluorizoline reduces chronic lymphocytic leukemia (CLL) cell viability through the upregulation of NOXA and BIM. Fluorizoline exerts antitumor action in a p53-independent manner. | ||||||||||||||||||||
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References
- [1]. Ana M Cosialls, et al. The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax. Haematologica. 2017 Sep;102(9):1587-1593. [Content Brief]
Keywords
