1372407-07-2
Chemical Structure
(s)-PF-4136309
Synonym(s): (s)-INCB8761
- CAS No.: 1372407-07-2
- Formula:C29H31F3N6O3
- Molecular Weight:568.59
IUPAC Name: N-(2-((S)-3-(((1s,4R)-4-hydroxy-4-(5-(pyrimidin-2-yl)pyridin-2-yl)cyclohexyl)amino)pyrrolidin-1-yl)-2-oxoethyl)-3-(trifluoromethyl)benzamide
InChIKey: ZNSVOHSYDRPBGI-UXWDXCIHSA-N
SMILES: O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
Biological Activity: (s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(s)-PF-4136309 | 98.93% | (s)-PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. | ||||||||||||||||||||
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Keywords
