1373391-77-5
Chemical Structure
Z-NCTS
- CAS No.: 1373391-77-5
- Formula:C68H70N14O8
- Molecular Weight:1211.37
InChIKey: KSINHSXBUUMTJG-YPKPFQOOSA-N
SMILES: CC1=NC2=C(C=C1)C=CC(NC(OCCCN(CCCOC(NC3=NC4=C(C=CC(C)=N4)C=C3)=O)CC(C=C5)=CC=C5/C=C\C(C=C6)=CC=C6CN(CCCOC(NC7=NC8=C(C=CC(C)=N8)C=C7)=O)CCCOC(NC9=NC%10=C(C=CC(C)=N%10)C=C9)=O)=O)=N2
Biological Activity: Z-NCTS is a small molecule that binds to mismatched RNA, recognizes the 5'-r (XGG)-3'/5'-r (XGG)-3' sequence, and acts as an RNA molecular glue. Z-NCTS induces the formation of tertiary structures in ribozymes and activates their RNA cleavage activity. As an RNA molecular glue, Z-NCTS enables small molecule-based strategies for regulating RNA structure and function. Z-NCTS binds to d (CGG)/d (CGG) double-stranded DNA, recognizes four guanine bases via hydrogen bonding, and stabilizes the double-stranded DNA. Z-NCTS binds to r (GGG)/r (GGG) double-stranded RNA and enhances the thermodynamic stability of the RNA duplex. Z-NCTS acts as a translation inhibitor by inducing the formation of stable hairpin structures in the 5'-UTR region of engineered mRNA, thereby blocking ribosomal access to the binding site[1][2][3].
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Z-NCTS | Z-NCTS is a small molecule that binds to mismatched RNA, recognizes the 5'-r (XGG)-3'/5'-r (XGG)-3' sequence, and acts as an RNA molecular glue. Z-NCTS induces the formation of tertiary structures in ribozymes and activates their RNA cleavage activity. As an RNA molecular glue, Z-NCTS enables small molecule-based strategies for regulating RNA structure and function. Z-NCTS binds to d (CGG)/d (CGG) double-stranded DNA, recognizes four guanine bases via hydrogen bonding, and stabilizes the double-stranded DNA. Z-NCTS binds to r (GGG)/r (GGG) double-stranded RNA and enhances the thermodynamic stability of the RNA duplex. Z-NCTS acts as a translation inhibitor by inducing the formation of stable hairpin structures in the 5'-UTR region of engineered mRNA, thereby blocking ribosomal access to the binding site. | |||||||||||||||||||||
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References
- [1]. Dohno C, et al. Molecular Glue for RNA: Regulating RNA Structure and Function through Synthetic RNA Binding Molecules. Chembiochem : a European journal of chemical biology. 2019 Dec 02;20(23):2903-2910. [Content Brief]
- [2]. Liu X, et al. Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing. Nucleic acids research. 2022 May 06;50(8):4769-4783.
- [3]. Dohno C, et al. A synthetic riboswitch that operates using a rationally designed ligand-RNA pair. Angewandte Chemie (International ed. in English). 2013 Sep 16;52(38):9976-9.
