138091-43-7
138091-43-7
Chemical Structure
WIN 62577
- CAS No.: 138091-43-7
- Formula:C29H31N3O
- Molecular Weight:437.58
InChIKey: YBCYJDNOPAFFOW-IMOYXPSTSA-N
SMILES: C[C@@]12[C@]3([H])[C@](CCC1=CC4=NC5=NC6=CC=CC=C6N5C=C4C2)([H])[C@@]7([H])[C@](CC3)([C@](O)(CC7)C#C)C
Biological Activity: WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2[1][2][3].
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WIN 62577 | WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2. | |||||||||||||||||||||
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References
- [1]. Briejer MR, et, al. Substance P-induced contractions of the guinea-pig proximal colon through stimulation of post-junctional tachykinin NK1 receptors. Eur J Pharmacol. 1993 Nov 30;250(1):181-3. [Content Brief]
- [2]. Lazareno S, et, al. Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors. J Mol Neurosci. 2003;20(3):363-7. [Content Brief]
- [3]. Singh A, et, al. Structural and Mechanistic Insights into the Main Protease (Mpro) Dimer Interface Destabilization Inhibitor: Unveiling New Therapeutic Avenues against SARS-CoV-2. Biochemistry. 2025 Apr 1;64(7):1589-1605. [Content Brief]
Keywords
