138117-50-7
Chemical Structure
Leteprinim
Synonym(s): AIT-082 free acid
- CAS No.: 138117-50-7
- Formula:C15H13N5O4
- Molecular Weight:327.29
IUPAC Name: 4-(3-(6-oxo-3,6-dihydro-9H-purin-9-yl)propanamido)benzoic acid
InChIKey: JMPOIZCOJJMTHI-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(NC(CCN2C=NC3=C2NC=NC3=O)=O)C=C1
Biological Activity: Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Leteprinim | Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. [Content Brief]
- [2]. Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93. [Content Brief]
- [3]. Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9. [Content Brief]
- [4]. Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10. [Content Brief]
Keywords
