138969-77-4
Chemical Structure
GR-891
- CAS No.: 138969-77-4
- Formula:C12H19FN2O5
- Molecular Weight:290.29
InChIKey: GURIQBJCVDAGLU-UHFFFAOYSA-N
SMILES: O=C1NC(N(C(CCOCCO)OC(C)C)C=C1F)=O
Biological Activity: GR-891 is an acyclic nucleoside 5-Fluorouracil (HY-90006) derivative. GR-891 exerts antiproliferative activity in human cancer cells and inhibits proliferation of human rhabdomyosarcoma cells. GR-891 induces terminal myogenic differentiation in human rhabdomyosarcoma cells, including modulation of desmin and vimentin expression. GR-891 is phosphorylated by kinases, incorporated into RNA, and releases acrolein. GR-891 can be used for the research of cancer and rhabdomyosarcoma[1][2].
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GR-891 | GR-891 is an acyclic nucleoside 5-Fluorouracil (HY-90006) derivative. GR-891 exerts antiproliferative activity in human cancer cells and inhibits proliferation of human rhabdomyosarcoma cells. GR-891 induces terminal myogenic differentiation in human rhabdomyosarcoma cells, including modulation of desmin and vimentin expression. GR-891 is phosphorylated by kinases, incorporated into RNA, and releases acrolein. GR-891 can be used for the research of cancer and rhabdomyosarcoma. | |||||||||||||||||||||
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References
- [1]. Marchal JA, et al. Acyclonucleosides, modified seco-nucleosides, and salicyl- or catechol-derived acyclic 5-fluorouracil O,N-acetals: antiproliferative activities, cellular differentiation and apoptosis. Curr Med Chem. 2009;16(9):1166-1183. [Content Brief]
- [2]. Marchal JA, et al. GR-891: a novel 5-fluorouracil acyclonucleoside prodrug for differentiation therapy in rhabdomyosarcoma cells. Br J Cancer. 1999 Feb;79(5-6):807-13. [Content Brief]
