1391108-10-3
Chemical Structure
BM-1074
- CAS 番号: 1391108-10-3
- Formula:C50H57ClN8O7S3
- Molecular Weight:1013.69
IUPAC Name: (R)-5-(4-chlorophenyl)-4-(3-(4-(4-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonamido)phenyl)piperazin-1-yl)phenyl)-1-isopropyl-2-methyl-N-(methylsulfonyl)-1H-pyrrole-3-carboxamide
InChIKey: GISBATIMZJHKJK-RRHRGVEJSA-N
SMILES: O=C(C1=C(C)N(C(C)C)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN(C)C)CSC7=CC=CC=C7)C([N+]([O-])=O)=C6)=O)C=C5)CC4)=C3)NS(=O)(C)=O
Biological Activity: BM-1074 is a potent and specific Bcl-2/Bcl-xL inhibitor with Ki values of < 1 nM and IC50 values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC50 values of 1-2 nM[1].
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BM-1074 | BM-1074 is a potent and specific Bcl-2/Bcl-xL inhibitor with Ki values of < 1 nM and IC50 values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC50 values of 1-2 nM. | |||||||||||||||||||||
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