1395886-20-0
1395886-20-0
Chemical Structure
AJI-214
- CAS No.: 1395886-20-0
- Formula:C17H13ClFN5O
- Molecular Weight:357.77
InChIKey: XSPXJYVALVHTAJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC2=NC=C(C(NC3=C(Cl)C=CC=C3)=N2)F)C=C1)N
Biological Activity: AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD)[1].
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AJI-214 | AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD). | |||||||||||||||||||||
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