AJI-214
AJI-214 is a dual-target inhibitor of Aurora kinase A and JAK2. AJI-214 directly blocks Aurora kinase A to inhibit T cell mitotic progression and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-214 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD).
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- CAS. Nr.: 1395886-20-0
- Formel: C17H13ClFN5O
- Molecular Weight:357.77
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Alle Aurora Kinase Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-468 | IC50 |
<0.3 μM
Compound: 9m
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Inhibition of autophosphorylation of Aurora A kinase at Thr288 in human MDA-MB-468 cells after 2 hrs by Western blot analysis
Inhibition of autophosphorylation of Aurora A kinase at Thr288 in human MDA-MB-468 cells after 2 hrs by Western blot analysis
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[PMID: 22803810] |
| MDA-MB-468 | IC50 |
<1 μM
Compound: 9m
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Inhibition of Aurora B kinase-mediated histone H3 phosphorylation at Ser10 in human MDA-MB-468 cells after 2 hrs by Western blot analysis
Inhibition of Aurora B kinase-mediated histone H3 phosphorylation at Ser10 in human MDA-MB-468 cells after 2 hrs by Western blot analysis
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[PMID: 22803810] |
Chemical Information
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CAS. Nr. 1395886-20-0
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Molecular Weight 357.77
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Formel C17H13ClFN5O
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SMILES
O=C(C1=CC=C(NC2=NC=C(C(NC3=C(Cl)C=CC=C3)=N2)F)C=C1)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AJI-214 Related Classifications
HY-164455 Related Classifications
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