1396397-03-7
Chemical Structure
PDE4-IN-20
- CAS No.: 1396397-03-7
- Formula:C19H22N2O5
- Molecular Weight:358.39
IUPAC Name: (E)-N'-(3,4-dimethoxybenzylidene)-3,4-dimethoxy-N-methylbenzohydrazide
InChIKey: RJGXXNTZSGVLHQ-UDWIEESQSA-N
SMILES: COC(C=C1/C=N/N(C)C(C2=CC(OC)=C(C=C2)OC)=O)=C(C=C1)OC
Biological Activity: PDE4-IN-20 is a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor with anti-TNF-α properties. PDE4-IN-20 exhibits significant biological activity in vitro and in vivo. The mechanism of action of PDE4-IN-20 is supported by molecular modeling studies, which reveal its binding mode with PDE4. PDE4-IN-20 was optimized in further conformational analysis and showed pharmacological characteristics similar to those of known PDE4 inhibitors[1].
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PDE4-IN-20 | PDE4-IN-20 is a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor with anti-TNF-α properties. PDE4-IN-20 exhibits significant biological activity in vitro and in vivo. The mechanism of action of PDE4-IN-20 is supported by molecular modeling studies, which reveal its binding mode with PDE4. PDE4-IN-20 was optimized in further conformational analysis and showed pharmacological characteristics similar to those of known PDE4 inhibitors. | |||||||||||||||||||||
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Keywords
