1404562-17-9
Chemical Structure
BRD6688
- CAS No.: 1404562-17-9
- Formula:C16H18N4O
- Molecular Weight:282.34
IUPAC Name: N-(2-amino-5-(pyridin-4-yl)phenyl)pyrrolidine-1-carboxamide
InChIKey: YZXBMJVMSBSGMM-UHFFFAOYSA-N
SMILES: O=C(N1CCCC1)NC2=C(N)C=CC(C3=CC=NC=C3)=C2
Biological Activity: BRD6688 is a selective HDAC inhibitor with IC50 values of 21 nM and 100 nM for HDAC1 and HDAC2, respectively. BRD6688 induces histone H4K12 and H3K9 acetylation. BRD6688 decreases CK2-induced HDAC2 phosphorylation. BRD6688 induces macrophage M1 to M2 polarization and renal cell proliferation. BRD6688 is used in research on neurodegenerative diseases, acute kidney injury, pain, and anxiety disorders[1][2][3][4][5][6][7].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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BRD6688 | 98.06% | BRD6688 is a selective HDAC inhibitor with IC50 values of 21 nM and 100 nM for HDAC1 and HDAC2, respectively. BRD6688 induces histone H4K12 and H3K9 acetylation. BRD6688 decreases CK2-induced HDAC2 phosphorylation. BRD6688 induces macrophage M1 to M2 polarization and renal cell proliferation. BRD6688 is used in research on neurodegenerative diseases, acute kidney injury, pain, and anxiety disorders. | ||||||||||||||||||||
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References
- [1]. Wagner FF, et al. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chemical science. 2015 Jan 01;6(1):804-815. [Content Brief]
- [2]. Ye K, et al. Down-regulating HDAC2-LTA4H pathway ameliorates renal ischemia-reperfusion injury. Biochimica et biophysica acta. Molecular basis of disease. 2025 Aug;1871(6):167889.
- [3]. Bonomi RE, et al. A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?. Complex psychiatry. 2022 Sep;8(1-2):13-27.
- [4]. Wang XM, et al. Dysregulation of EAAT2 and VGLUT2 spinal glutamate transports via histone deacetylase 2 (HDAC2) contributes to paclitaxel-induced painful neuropathy. Molecular Cancer Therapeutics. 2020 Oct 1;19(10):2196-209.
- [5]. Lavertu-Jolin M, et al. Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories. Molecular psychiatry. 2023 Jul;28(7):2946-2963.
- [6]. Algate K, et al. Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. Journal of cellular biochemistry. 2020 Jan;121(1):244-258. [Content Brief]
- [7]. Best AJ, et al. High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters. Nature communications. 2024 Jul 27;15(1):6328. [Content Brief]
