141997-14-0
141997-14-0
Chemical Structure
sFTX-3.3
- CAS. Nr.: 141997-14-0
- Formula:C12H29N7O
- Molecular Weight:287.40
IUPAC Name: (S)-2-amino-N-(3-((3-aminopropyl)amino)propyl)-5-guanidinopentanamide
InChIKey: CHIHEOCAOMXRKN-JTQLQIEISA-N
SMILES: O=C(NCCCNCCCN)[C@@H](N)CCCNC(N)=N
Biological Activity: sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels[1][2].
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sFTX-3.3 | sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels. | |||||||||||||||||||||
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References
- [1]. Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44(3):315-21. [Content Brief]
- [2]. T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50(4):939-46. [Content Brief]
