1421340-50-2
Chemical Structure
CDK9-IN-53
- CAS No.: 1421340-50-2
- Formula:C21H24N8S
- Molecular Weight:420.54
IUPAC Name: 2-((3-(1,4-diazepan-1-yl)phenyl)amino)-4-(4-methyl-2-(methylamino)thiazol-5-yl)pyrimidine-5-carbonitrile
InChIKey: BKOYUSKBPMSUBK-UHFFFAOYSA-N
SMILES: N#CC=1C=NC(=NC1C=2SC(=NC2C)NC)NC3=CC=CC(=C3)N4CCNCCC4
Biological Activity: CDK9-IN-53 is a potent and selective CDK9 inhibitor with a Ki of 7 nM and an IC50 of 14 nM against CDK9/Cyclin T1. CDK9-IN-53 achieves highly selective inhibition by competitively binding to the ATP pocket of CDK9, thereby blocking RNAPII transcription and downregulating the anti-apoptotic protein Mcl-1, ultimately triggering Caspase-dependent apoptosis in cancer cells. CDK9-IN-53 can be used for research on chronic lymphocytic leukemia[1].
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CDK9-IN-53 | CDK9-IN-53 is a potent and selective CDK9 inhibitor with a Ki of 7 nM and an IC50 of 14 nM against CDK9/Cyclin T1. CDK9-IN-53 achieves highly selective inhibition by competitively binding to the ATP pocket of CDK9, thereby blocking RNAPII transcription and downregulating the anti-apoptotic protein Mcl-1, ultimately triggering Caspase-dependent apoptosis in cancer cells. CDK9-IN-53 can be used for research on chronic lymphocytic leukemia. | |||||||||||||||||||||
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