1423743-97-8
Chemical Structure
LZ1 peptide
- CAS No.: 1423743-97-8
- Formula:C113H167N33O15
- Molecular Weight:2227.75
InChIKey: AEGLGCLRXLHQRT-YZCAGTBWSA-N
SMILES: CC(C)[C@H](N)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@H](C(N)=O)C(C)C)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)=O)=O)=O)=O)=O
Biological Activity: LZ1 peptide acts as a Pyruvate kinase inhibitor, antimicrobial agent, and antimalarial agent. LZ1 peptide reduces ATP production and inhibits the malaria parasite Plasmodium falciparum. LZ1 peptide exhibits activity against Plasmodium berghei in mice and reduces parasitemia. LZ1 peptide shows favorable antimicrobial activity against pathogens associated with acne vulgaris. LZ1 peptide possesses anti-inflammatory effects. LZ1 peptide can be used in malaria-related research[1][2].
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LZ1 peptide | LZ1 peptide acts as a Pyruvate kinase inhibitor, antimicrobial agent, and antimalarial agent. LZ1 peptide reduces ATP production and inhibits the malaria parasite Plasmodium falciparum. LZ1 peptide exhibits activity against Plasmodium berghei in mice and reduces parasitemia. LZ1 peptide shows favorable antimicrobial activity against pathogens associated with acne vulgaris. LZ1 peptide possesses anti-inflammatory effects. LZ1 peptide can be used in malaria-related research. | |||||||||||||||||||||
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- [1]. Fang Y, et al. In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin. Toxins. 2019 Jun 30;11(7):379. [Content Brief]
- [2]. Salimo ZM, et al. Toxins from Animal Venoms as a Potential Source of Antimalarials: A Comprehensive Review. Toxins. 2023 Jun 03;15(6):375. [Content Brief]
Keywords
