1425944-22-4
1425944-22-4
Chemical Structure
CYD-2-11
- CAS. Nr.: 1425944-22-4
- Formula:C22H18N2O3
- Molecular Weight:358.39
IUPAC Name: (E)-2-(2-((2-nitro-9H-fluoren-9-ylidene)methyl)phenoxy)ethan-1-amine
InChIKey: BJIFXXDQMBHYKG-DEDYPNTBSA-N
SMILES: NCCOC1=CC=CC=C1/C=C2C3=C(C=CC([N+]([O-])=O)=C3)C4=C/2C=CC=C4
Biological Activity: CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2].
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CYD-2-11 | 99.92% | CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer. | ||||||||||||||||||||
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References
- [1]. Liu G, et al. Structure-activity relationship studies on Bax activator SMBA1 for the treatment of ER-positive and triple-negative breast cancer. Eur J Med Chem. 2019 Sep 15;178:589-605. [Content Brief]
- [2]. Li R, et al. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017 Jun 1;77(11):3001-3012. doi: 10.1158/0008-5472.CAN-16-2356. Epub 2017 Apr 5. [Content Brief]
