2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. CYD-2-11

CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer.

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CYD-2-11 Chemical Structure

CYD-2-11 Chemical Structure

CAS No. : 1425944-22-4

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CYD-2-11 Related Antibodies

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Description

CYD-2-11 is a selective Bax agonist with a Ki value of 34.1 nM. CYD-2-11 induces cell apoptosis and shows antiproliferative activity to breast cancer MDA-MB-231 and MCF-7 cell lines with IC50 values of 3.22 and 3.81 μM, respectively. CYD-2-11 suppresses tumor growth in MDA-MB-231 tumor models. CYD-2-11 can be used for the research of breast and lung cancer[1][2].

In Vitro

CYD-2-11 (0-100 μM; 48 h) shows anti-proliferation effects to breast cancer cells[1].
CYD-2-11 (5 μM; 48 h) selectively binds to Bax protein and induces apoptosis in NSCLC and SCLC cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYD-2-11 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cell lines
Concentration: 0.01, 0.1, 1, 5, 10 and 100 µM
Incubation Time: 48 hours
Result: Inhibited cell proliferation of T47D, MCF-7, MDA-MB-231, MDA-MB-468 and MCF-10A cells with IC50 values of 4.37, 9.47, 3.81, 3.22 and 8.73 μM, respectively.

Apoptosis Analysis[2]

Cell Line: SCLC and NSCLC cell lines
Concentration: 5 µM
Incubation Time: 48 hours
Result: Induced cell apoptosis in both SCLC and NSCLC cells with a higher effect than SMBA1.
In Vivo

CYD-2-11 (20 mg/kg; i.p.; once daily for 7 days) inhibits tumor growth[1].
CYD-2-11 (40 mg/kg; i.p.; once daily for 14 days) represses lung cancer growth and overcomes rapalog resistance with the combination of RAD001 (1 mg/kg) in murine lung cancer models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice with MDA-MB-231 tumor xenografts[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; once daily for 7 days
Result: Exhibited a 57% inhibition rate of MDA-MB-231 tumor growth in vivo.
Molecular Weight

358.39

Formula

C22H18N2O3
CAS No.
SMILES

NCCOC1=CC=CC=C1/C=C2C3=C(C=CC([N+]([O-])=O)=C3)C4=C/2C=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYD-2-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYD-2-111425944-22-4Bcl-2 FamilyApoptosisER-positivetriple-negativebreast cancerSMBA1apoptosisanti-proliferationSCLCNSCLCmurine lung cancerRAD001miceInhibitorinhibitorinhibit

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