1428439-79-5
1428439-79-5
Chemical Structure
BChE-IN-20
- CAS No.: 1428439-79-5
- Formula:C27H39N5O2
- Molecular Weight:465.63
InChIKey: UNBZCEWKTVYZBB-ZBJSNUHESA-N
SMILES: O=C(OC)/C(C1)=C/N(C(C)C)CCC2=C1C(NCCCN(CC)CC)=NC(C3=CC=CC=C3)=N2
Biological Activity: BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes.
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BChE-IN-20 | BChE-IN-20 (compound 7c) is a highly potent BChE-selective inhibitor and exhibits IC50s of 105 and 2.3 nM for eqBChE and hBChE, respectively. BChE-IN-20 inhibits P glycoprotein with IC50 of 0.27 μM. BChE-IN-20 is a promising template to improve design and development of BChE-selective ligands of pharmaceutical interest, including inhibitors and fluorogenic probes. | |||||||||||||||||||||
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Keywords
