142974-51-4
Chemical Structure
Gallensre
Synonym(s): S 0960
- CAS No.: 142974-51-4
- Formula:C48H79NO8
- Molecular Weight:798.16
IUPAC Name: (R)-4-((3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-3-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChIKey: GCJPHGQNZBNLBM-ZPKFPLNNSA-N
SMILES: O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]4(C)[C@](C1)(C[C@@H](NC(CC[C@@H](C)[C@@]5([C@]6(C)[C@@](CC5)([C@]7([C@](C[C@@H]6O)([C@]8(C)[C@](C[C@H]7O)(C[C@H](O)CC8)[H])[H])[H])[H])[H])=O)CC4)[H])[H])[H])[H]
Biological Activity: Gallensre (S 0960) is an apical sodium-dependent bile acid transporter inhibitor (IC50 = 5.8 μmol/L). Gallensre inhibits bile salt reabsorption in a rat model. Gallensre can be used to study metabolic diseases such as bile acid cycling[1].
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Gallensre | Gallensre (S 0960) is an apical sodium-dependent bile acid transporter inhibitor (IC50 = 5.8 μmol/L). Gallensre inhibits bile salt reabsorption in a rat model. Gallensre can be used to study metabolic diseases such as bile acid cycling. | |||||||||||||||||||||
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