143137-35-3
143137-35-3
Chemical Structure
RS-56812
- CAS No.: 143137-35-3
- Formula:C18H21N3O2
- Molecular Weight:311.38
IUPAC Name: 2-(1-methyl-1H-indol-3-yl)-2-oxo-N-(quinuclidin-3-yl)acetamide
InChIKey: ZNAPADWWBWFMCQ-UHFFFAOYSA-N
SMILES: O=C(NC1CN2CCC1CC2)C(C3=CN(C)C4=C3C=CC=C4)=O
Biological Activity: RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease)[1][2].
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RS-56812 | RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease). | |||||||||||||||||||||
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References
- [1]. Terry AV Jr, et al. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8(1):49-54. [Content Brief]
- [2]. Boakye PA, et al. 5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterol Motil. 2012 Jan;24(1):e27-40. [Content Brief]
