1435781-74-0
1435781-74-0
Chemical Structure
WKYMVM-NH2 TFA
- CAS No.: 1435781-74-0
- Formula:C43H62F3N9O9S2
- Molecular Weight:970.13
InChIKey: MYVYQWVNXDVTBW-CZPFDPCBSA-N
SMILES: CSCC[C@@H](C(N)=O)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](CC1=CC=C(C=C1)O)NC([C@H](CCCCN)NC([C@H](CC2=CNC3=CC=CC=C23)N)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Biological Activity: WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].
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WKYMVM-NH2 TFA | 99.67% | WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase. | ||||||||||||||||||||
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References
- [1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93. [Content Brief]
- [2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6. [Content Brief]
- [3]. Sang Doo Kim, et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013 Sep; 45(9): e40. [Content Brief]
Keywords
