143692-18-6
143692-18-6
Chemical Structure
LY-300168
Synonym(s): GYKI 53655
- CAS No.: 143692-18-6
- Formula:C19H20N4O3
- Molecular Weight:352.39
IUPAC Name: 5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d][1,2]diazepine-7-carboxamide
InChIKey: SMGACXZFVXKEAX-UHFFFAOYSA-N
SMILES: O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3CC1C)NC
Biological Activity: LY 300168 (GYKI 53655) is a non-competitive, blood-brain-barrier permeable AMPA receptor antagonist. LY 300168 attenuates hippocampal injury. LY 300168 blocks the sound-induced clonic and tonic convulsions[1][2].
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LY-300168 | LY 300168 (GYKI 53655) is a non-competitive, blood-brain-barrier permeable AMPA receptor antagonist. LY 300168 attenuates hippocampal injury. LY 300168 blocks the sound-induced clonic and tonic convulsions. | |||||||||||||||||||||
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References
- [1]. Liu XH, et al. The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents. Neurosci Lett. 1997 Oct 10;235(1-2):93-7. [Content Brief]
- [2]. Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55(3):387-91. [Content Brief]
