LY-300168
Based on 1 publication(s) in Google Scholar
LY 300168 (GYKI 53655) is a non-competitive, blood-brain-barrier permeable AMPA receptor antagonist. LY 300168 attenuates hippocampal injury. LY 300168 blocks the sound-induced clonic and tonic convulsions.
For research use only. We do not sell to patients.
- CAS No.: 143692-18-6
- Formula: C19H20N4O3
- Molecular Weight:352.39
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) LY-300168
MoreAll iGluR Isoforms
More
Biological Activity
|
AMPA Receptor |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Oocyte | EC50 |
100 μM
Compound: GYKI-53655
|
Activity at recombinant GluA2 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on glutamate/trichloromethiazide-induced current
Activity at recombinant GluA2 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on glutamate/trichloromethiazide-induced current
|
[PMID: 20096591] |
| Oocyte | EC50 |
28 μM
Compound: GYKI-53655
|
Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on glutamate/trichloromethiazide-induced current
Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on glutamate/trichloromethiazide-induced current
|
[PMID: 20096591] |
Chemical Information
-
CAS No. 143692-18-6
-
Molecular Weight 352.39
-
Formula C19H20N4O3
-
SMILES
O=C(N1N=C(C2=CC=C(N)C=C2)C3=CC(OCO4)=C4C=C3CC1C)NC
-
Synonyms
GYKI 53655
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Nat Neurosci
Excitatory synapses onto axonic spines jump-start action potentials and route information flow. [Abstract]2026 May 15. PMID: 42141306
Purity & Documentation
References
[1]. Liu XH, et al. The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents. Neurosci Lett. 1997 Oct 10;235(1-2):93-7. [Content Brief]
[2]. Szabados T, et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655. Brain Res Bull. 2001 Jun;55(3):387-91. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LY-300168 Related Classifications
HY-136844 Related Classifications
Powered by Bioz