144092-66-0
Chemical Structure
A-39355
- CAS No.: 144092-66-0
- Formula:C28H39Cl2N3O
- Molecular Weight:504.53
IUPAC Name: 5-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl)-6,7,8,9,10,11-hexahydro-5H-cycloocta[b]indole dihydrochloride
InChIKey: PHPDAOIDYWRHKK-UHFFFAOYSA-N
SMILES: COC1=C(N2CCN(CCCN3C4=C(C5=C3CCCCCC5)C=CC=C4)CC2)C=CC=C1.Cl.Cl
Biological Activity: A-39355 is a compound that can overcome multidrug resistance and has the activity of reversing multidrug resistance. A-39355 can enhance the cytotoxicity of antitumor compounds in multidrug-resistant cells, increase the accumulation of compounds in cells, inhibit the efflux of compounds, and compared with calcium antagonists, it has no serious hypotensive effect. Its activity may be unrelated to the ability to block calcium transport.
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A-39355 | A-39355 is a compound that can overcome multidrug resistance and has the activity of reversing multidrug resistance. A-39355 can enhance the cytotoxicity of antitumor compounds in multidrug-resistant cells, increase the accumulation of compounds in cells, inhibit the efflux of compounds, and compared with calcium antagonists, it has no serious hypotensive effect. Its activity may be unrelated to the ability to block calcium transport. | |||||||||||||||||||||
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Keywords
