144510-04-3
Chemical Structure
8-Br-PET-cGMP
- CAS No.: 144510-04-3
- Formula:C18H15BrN5O7P
- Molecular Weight:524.22
IUPAC Name: 2-bromo-3-((4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl)-6-phenyl-3,5-dihydro-9H-imidazo[1,2-a]purin-9-one
InChIKey: FYTFYLRNLQRROD-XNIJJKJLSA-N
SMILES: O=C(N(C=C(C1=CC=CC=C1)N2)C2=N3)C4=C3N(C(Br)=N4)[C@H]5[C@H](O)[C@H](OP6(O)=O)[C@@H](CO6)O5
Biological Activity: 8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function[1].
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8-Br-PET-cGMP | 8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function. | |||||||||||||||||||||
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