1445475-53-5
Chemical Structure
Isograndifoliol
- CAS No.: 1445475-53-5
- Formula:C19H26O3
- Molecular Weight:302.41
IUPAC Name: (4aS,11bR)-10-hydroxy-11b-(hydroxymethyl)-4,4,8-trimethyl-1,2,3,4,4a,5,6,11b-octahydro-9H-cyclohepta[a]naphthalen-9-one
InChIKey: LZLHHGFIKUAWST-LPHOPBHVSA-N
SMILES: CC1=CC2=C(C=C(C1=O)O)[C@](CCCC3(C)C)(CO)[C@H]3CC2
Biological Activity: Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].
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Isograndifoliol | Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases. | |||||||||||||||||||||
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- [1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475. [Content Brief]
- [2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348. [Content Brief]
- [3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61. [Content Brief]
Keywords
