1446971-41-0
1446971-41-0
Chemical Structure
ZLc-002
- CAS No.: 1446971-41-0
- Formula:C10H17NO5
- Molecular Weight:231.25
IUPAC Name: methyl (3-methoxy-3-oxopropanoyl)-D-valinate
InChIKey: BWPKYDAJBOUZDX-SECBINFHSA-N
SMILES: COC(CC(N[C@H](C(C)C)C(OC)=O)=O)=O
Biological Activity: ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation[1][2][3].
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ZLc-002 | ZLc-002 is a selective inhibitor of nNOS-Capon coupling. ZLc-002 suppresses inflammatory nociception and chemotherapy-induced neuropathic pain. ZLc-002 can be used for the research of anxiety disorder and inflammation. | |||||||||||||||||||||
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References
- [1]. Ni HY, et al.Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity. Stroke. 2019 Mar;50(3):728-737. [Content Brief]
- [2]. Zhu LJ, et al. nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety. Br J Pharmacol. 2020 Aug;177(16):3674-3690. [Content Brief]
- [3]. Zhu LJ, et al.CAPON-nNOS coupling can serve as a target for developing new anxiolytics. Nat Med. 2014 Sep;20(9):1050-4. doi: 10.1038/nm.3644. Epub 2014 Aug 17. [Content Brief]
Keywords
