14494-37-2
14494-37-2
Chemical Structure
Cu(II) protoporphyrin IX
- CAS No.: 14494-37-2
- Formula:C34H32CuN4O4
- Molecular Weight:624.19
InChIKey: ASFPSNQTLAUXFI-RGGAHWMASA-L
SMILES: [O-]C(CCC(C1=CC(C(CCC([O-])=O)=C2C)=[N](C2=C3)[Cu+2]4([N-]5C3=C6C)[N-]1C7=CC(C(C=C)=C8C)=[N]4C8=CC5=C6C=C)=C7C)=O.[H+].[H+]
Biological Activity: Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cu(II) protoporphyrin IX | 95.60% | Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair. | ||||||||||||||||||||
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References
- [1]. Jozkowicz A, et al. Heme oxygenase-1 in tumors: is it a false friend?. Antioxid Redox Signal. 2007;9(12):2099-2117. [Content Brief]
- [2]. Abraham NG, et al. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med. 2005;39(1):1-25. [Content Brief]
- [3]. Kim DH, et al. Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells. J Pharmacol Exp Ther. 2008;325(3):833-840. [Content Brief]
Keywords
