145071-44-9
Chemical Structure
Itameline
Synonym(s): RU 47213
- CAS No.: 145071-44-9
- Formula:C14H15ClN2O3
- Molecular Weight:294.73
IUPAC Name: 4-chlorophenyl (E)-5-((methoxyimino)methyl)-3,6-dihydropyridine-1(2H)-carboxylate
InChIKey: CTVQNEVLCGSTKL-CXUHLZMHSA-N
SMILES: O=C(N1CCC=C(/C=N/OC)C1)OC2=CC=C(Cl)C=C2
Biological Activity: Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat[1].
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Itameline | Itameline (RU 47213) is a prodrug with oral and long-lasting cholinergic activity. Itameline is a novel tetrahydropyridine-oxime that is cleaved in vivo to form an active metabolite, RU 35963. RU 35963 is a muscarinic receptor agonist that is nonselective with respect to receptor subtypes. Itameline possesses the capacity to reduce memory deficits induced by an impairment of cholinergic transmission in the rat. | |||||||||||||||||||||
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Keywords
