145209-39-8
Chemical Structure
Cymserine
- CAS No.: 145209-39-8
- Formula:C23H29N3O2
- Molecular Weight:379.50
InChIKey: NKJRRVBTMYRXRB-GGAORHGYSA-N
SMILES: C[C@]12C3=CC(OC(NC4=CC=C(C=C4)C(C)C)=O)=CC=C3N([C@@]1([H])N(CC2)C)C
Biological Activity: Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease[1].
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Cymserine | Cymserine is a blood-brain barrier-permeable butyrylcholinesterase (BuChE) inhibitor with an IC50 value of 56.43 nM and a Ki of 38 nM. Cymserine binds to the catalytic domain of BuChE in a concentration-dependent manner to form a stable carbamylated enzyme complex, and exhibits BuChE selectivity over acetylcholinesterase due to its structural compatibility with the larger acyl-binding pocket of BuChE. Cymserine can be used in the research of Alzheimer's disease. | |||||||||||||||||||||
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Keywords
