1453221-07-2
1453221-07-2
Chemical Structure
IDR-1018
- CAS No.: 1453221-07-2
- Formula:C71H126N26O12
- Molecular Weight:1535.93
InChIKey: VNWKTOKETHGBQD-UHFFFAOYSA-N
SMILES: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](C(C)C)NC([C@H](C)NC([C@H](C(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)C(C)C)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O
Biological Activity: IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate)[1][2].
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IDR-1018 | IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate). | |||||||||||||||||||||
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References
- [1]. Hashem Etayash, Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response. J. Med. Chem. 2021, 64, 22, 16854-16863.
- [2]. Hashem Etayash, et al. Correction to “Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response”. J. Med. Chem. 2022, 65, 3, 2710-2711.
