1454902-97-6
1454902-97-6
Chemical Structure
Elevenostat
Synonym(s): JB3-22
- CAS No.: 1454902-97-6
- Formula:C16H17N3O4
- Molecular Weight:315.32
IUPAC Name: N-hydroxy-4-((3-(2-methoxyphenyl)ureido)methyl)benzamide
InChIKey: DZHNFBYCLJKJID-UHFFFAOYSA-N
SMILES: O=C(NO)C1=CC=C(CNC(NC2=CC=CC=C2OC)=O)C=C1
Biological Activity: Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Elevenostat | 95.07% | Elevenostat (JB3-22) is a selective HDAC11 inhibitor with an IC50 of 0.235 µM. Elevenostat can induce apoptosis of multiple myeloma cells and has anti-tumor effect. In addition, Elevenostat inhibits the maturation of mouse oocytes. | ||||||||||||||||||||
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References
- [1]. Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17. [Content Brief]
- [2]. Sui L, et al. HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and α-tubulin acetylation. Cell Cycle. 2020 Feb;19(3):354-362.
