1458731-58-2
Chemical Structure
BMV109
- CAS No.: 1458731-58-2
- Formula:C107H108F4N10O23S5
- Molecular Weight:2138.37
InChIKey: KDFGXWUMTFTKSD-XYZCXLSZSA-N
SMILES: O=S(C1=C(C=CC=C1)C(C2=CC=C(N3C4=CC=C(S(=O)([O-])=O)C=C4CC3)C=C2O5)=C(C=C/6)C5=CC6=[N+]7C8=CC=C(S(=O)(O)=O)C=C8CC/7)(N9CCC(CC9)C(NCCNC(C%10=C(C(F)=C(C(F)=C%10F)OCC([C@H](CCCCNC(CCCCCN%11C%12=CC=C(S(=O)(O)=O)C=C%12C(C)(/C%11=C/C=C/C=C/C%13=[N+](C%14=CC=C(S(=O)([O-])=O)C=C%14C%13(C)C)CC)C)=O)NC([C@@H](NC(OCC%15=CC=CC=C%15)=O)CC%16=CC=CC=C%16)=O)=O)F)=O)=O)=O
Biological Activity: BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging[1][2].
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BMV109 | BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging. | |||||||||||||||||||||
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- [1]. Martijn Verdoes, et al. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity. J Am Chem Soc. 2013 Oct 2;135(39):14726-30. [Content Brief]
- [2]. Steven Sensarn, et al. A Clinical Wide-Field Fluorescence Endoscopic Device for Molecular Imaging Demonstrating Cathepsin Protease Activity in Colon Cancer. Mol Imaging Biol. 2016 Dec;18(6):820-829. [Content Brief]
Keywords
