145969-31-9
145969-31-9
Chemical Structure
OPC-14523 hydrochloride
- CAS No.: 145969-31-9
- Formula:C23H29Cl2N3O2
- Molecular Weight:450.40
IUPAC Name: 1-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-5-methoxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
InChIKey: SFOVXVXPFWJNBL-UHFFFAOYSA-N
SMILES: O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)C4=C(C(OC)=CC=C4)CC1.[H]Cl
Biological Activity: OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 hydrochloride shows antidepressant-like activity[1][2].
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OPC-14523 hydrochloride | 99.95% | OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 hydrochloride shows antidepressant-like activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.98
HY-116594OPC-14523 free base -
Similarity Score 0.66
HY-W705137Aripiprazole impurity 14 -
Similarity Score 0.65
HY-Z7631Aripiprazole impurity 33 -
Similarity Score 0.65
HY-Z6691Aripiprazole impurity 17 -
Similarity Score 0.61
HY-173431Dopamine D4 receptor ligand 3 -
Similarity Score 0.59
HY-W725833Trazodone impurity 7 dihydrochloride -
Similarity Score 0.59
HY-Z19614Aripiprazole impurity 16 -
Similarity Score 0.59
HY-14546RAripiprazole (Standard) -
Similarity Score 0.59
HY-W587508Trazodone impurity 7 -
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References
- [1]. Tottori K, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology. 2001;41(8):976-988. [Content Brief]
- [2]. Bermack JE, et al. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. J Pharmacol Exp Ther. 2004;310(2):578-583. [Content Brief]
