1464021-70-2
Chemical Structure
N1-Propargylpseudouridine
- CAS No.: 1464021-70-2
- Formula:C12H14N2O6
- Molecular Weight:282.25
IUPAC Name: 5-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-(prop-2-yn-1-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: KMLHIDMUNPEGKF-KYXWUPHJSA-N
SMILES: O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(CC#C)C2=O)O[C@@H]1CO
Biological Activity: N1-Propargylpseudouridine (see GL102032) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. N1-Propargylpseudouridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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N1-Propargylpseudouridine | N1-Propargylpseudouridine (see GL102032) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. N1-Propargylpseudouridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | |||||||||||||||||||||
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