14698-07-8
Chemical Structure
Tipepidine citrate
- CAS No.: 14698-07-8
- Formula:C21H25NO7S2
- Molecular Weight:467.56
IUPAC Name: 3-(di(thiophen-2-yl)methylene)-1-methylpiperidine 2-hydroxypropane-1,2,3-tricarboxylate
InChIKey: WQOYJMWVNIGIQR-UHFFFAOYSA-N
SMILES: CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.O=C(CC(C(O)=O)(O)CC(O)=O)O
Biological Activity: Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice[1][2][3][4].
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Tipepidine citrate | Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice. | |||||||||||||||||||||
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- [1]. Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current. Neuroscience. 2013 Nov 12;252:24-34. [Content Brief]
- [2]. Kawaura K, et al. Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behav Brain Res. 2016 Apr 1;302:269-78. [Content Brief]
- [3]. Kawaura K, et al. Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test. Eur J Pharmacol. 2011 Jan 25;651(1-3):106-8. [Content Brief]
- [4]. Sawamoto A, et al. Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice. FASEB J. 2024 Mar 15;38(5):e23542. [Content Brief]
Keywords
