1472616-48-0
1472616-48-0
Chemical Structure
HSP90i
- CAS No.: 1472616-48-0
- Formula:C22H27N5O3
- Molecular Weight:409.48
InChIKey: HKMZKKVEPAWSQP-UHFFFAOYSA-N
SMILES: CC(C1=C(C=C(C(C2=NN=C(N2C3=CC=C(C=C3)CN4CCNCC4)O)=C1)O)O)C
Biological Activity: HSP90i is a HSP90 inhibitor. HSP90i can be used as a drug intermediate to synthesize LYTACs, such as dPDL1-4 (HY-174468)[1][2].
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HSP90i | HSP90i is a HSP90 inhibitor. HSP90i can be used as a drug intermediate to synthesize LYTACs, such as dPDL1-4 (HY-174468). | |||||||||||||||||||||
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References
- [1]. Zhang D, et al. Extracellular HSP90-Facilitated Degradation of Extracellular and Membrane Proteins by Bifunctional Small Molecules. J Med Chem. 2025 Jun 26;68(12):12641-12657. [Content Brief]
- [2]. Rastogi S, et al. An update on the status of HSP90 inhibitors in cancer clinical trials. Cell Stress Chaperones. 2024 Aug;29(4):519-539. [Content Brief]
