1476-98-8
1476-98-8
Chemical Structure
Hydroquinidine hydrochloride
- CAS No.: 1476-98-8
- Formula:C20H27ClN2O2
- Molecular Weight:362.90
IUPAC Name: (S)-((1S,2R,4S,5S)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol hydrochloride
InChIKey: MULXTQKDWYBJMO-JMVZEAGUSA-N
SMILES: O[C@@H](C1=C(C=C(OC)C=C2)C2=NC=C1)[C@@]3([H])C[C@@]4([H])[C@H](CC)C[N@@]3CC4.Cl
Biological Activity: Hydroquinidine hydrochloride is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine hydrochloride prolongs the QT interval and has antiarrhythmic efficacy[1][2][3][4][5].
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Hydroquinidine hydrochloride | Hydroquinidine hydrochloride is a potent ion channel blocker, which exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Hydroquinidine hydrochloride prolongs the QT interval and has antiarrhythmic efficacy. | |||||||||||||||||||||
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References
- [1]. Yavuz M, et al. A potent ion channel blocker, hydroquinidine, exhibits strong anti-cancer activity on colon, pancreatic, and hepatocellular cancer cells. Mol Biol Rep. 2023 Mar;50(3):2611-2621. [Content Brief]
- [2]. Mazzanti A, et al. Hydroquinidine Prevents Life-Threatening Arrhythmic Events in Patients With Short QT Syndrome. J Am Coll Cardiol. 2017 Dec 19;70(24):3010-3015. [Content Brief]
- [3]. Chimienti M, et al. Comparison of the effectiveness of dihydroquinidine and quinidine on ventricular ectopy after acute and chronic administration. Cardiovasc Drugs Ther. 1988 Dec;2(5):679-86. [Content Brief]
- [4]. Hermida JS, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004 May 19;43(10):1853-60. [Content Brief]
