147841-68-7
Chemical Structure
HIV gp120 (318-327)
- CAS No.: 147841-68-7
- Formula:C48H80N16O12
- Molecular Weight:1073.25
InChIKey: OPTVPTKXPSEPBD-JLHVISHLSA-N
SMILES: CC[C@H](C)[C@@H](C(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@H](C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]2N(CCC2)C(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding[1][2].
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HIV gp120 (318-327) | HIV gp120 (318-327) is a short sequence of the HIV-1 strain IIIB envelope peptide (rgpgrafvti) that corresponds to the conserved C-terminal region of the glycoprotein. HIV gp120 (318-327) is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIV gp120 (318-327) lacks the A2 anchor residues recognized by epitope-specific CTLs but has structural features that confer promiscuous A2 binding. | |||||||||||||||||||||
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References
- [1]. Kmieciak D, et al. The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis. J Immunol. 1998 Jun 1;160(11):5676-83. [Content Brief]
- [2]. Gu L, et al. A recombinant adenovirus-based vector elicits a specific humoral immune response against the V3 loop of HIV-1 gp120 in mice through the "Antigen Capsid-Incorporation" strategy. Virol J. 2014 Jun 16;11:112. [Content Brief]
